What factors can contribute to compromised tissue tolerance?

Compromised tissue tolerance refers to the skin and underlying tissues' reduced ability to withstand pressure, shear, moisture, and other factors that can lead to pressure injuries or other skin breakdowns. The correct choice focuses on several critical factors known to negatively impact the integrity and resilience of tissue.

Loss of subcutaneous (SubQ) tissue can significantly reduce the cushioning layer that protects skin from pressure and shear forces. As individuals age or due to certain medical conditions, this loss can occur, leading to an increased risk of injury to the underlying structures.

Fever can lead to increased metabolic demand and changes in skin perfusion, potentially compromising skin integrity and making tissues more susceptible to injury.

The use of vasopressors, typically employed in critical care to manage blood pressure, may reduce peripheral circulation, which is crucial for tissue perfusion and nourishment. Impaired blood flow can lead to ischemia, further weakening tissue resilience.

Tobacco use is associated with impaired circulation due to vasoconstriction and decreased oxygenation of tissues. This can lead to delayed wound healing and an increased susceptibility to injury.

In contrast, the other options include factors that either promote healthy tissue or do not significantly contribute to compromised tissue tolerance. Regular exercise and a healthy diet,