Which factor can significantly delay wound healing?

Age and comorbidities are known factors that can significantly delay wound healing due to several physiological and pathological mechanisms. As people age, their skin loses elasticity, thickness, and the ability to regenerate cells effectively. This natural decline can hinder the healing process. Additionally, comorbidities such as diabetes, vascular disease, and immune disorders can compromise blood flow and reduce the body's capacity to heal quickly. These conditions influence the inflammatory response, collagen synthesis, and overall tissue repair, creating an environment where wounds are slower to heal.

On the other hand, adequate nutrition supports wound healing by providing the necessary vitamins and minerals required for tissue repair. Regular exercise promotes circulation and can help maintain health, thereby supporting the healing process. Frequent dressing changes are part of wound management but do not inherently delay healing unless done improperly, which may disrupt the healing tissue or introduce infection. Thus, the presence of age and comorbidities emerges as the most critical factor in delaying wound healing.